Reversing Renal Medullary Hypoxia and Acute Kidney Injury in Sepsis

Grant number: 1188514 | Funding period: 2020 - 2023

Completed

Abstract

Acute kidney injury is a major unresolved problem in patients with sepsis, which greatly increases their risk of death. We have shown that a reduced blood supply and oxygen delivery to the inner region of the kidneys, the medulla, likely leads to septic kidney failure. Recently, we found a novel therapy that prevents these changes and the development of septic kidney failure. We will validate, optimise and assess the safety of this new therapy to enable the design of human trials.

Related publications (9)

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Effects of tempol on renal medullary tissue hypoxia in an ovine model of Gram-negative septic acute kidney injury

R Peiris, A Trask-Marino, A Jufar, AH Betrie, A Southon, SG Hood, R Bellomo, AH Hulst, CN May, CPC Ow, YR Lankadeva

2025-01-01

Renal arterial infusion of tempol (RAT) at the onset of Gram-negative sepsis can prevent sepsis-induced medullary tissue hypoxia a..

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Renal arterial infusion of tempol prevents medullary hypoperfusion, hypoxia, and acute kidney injury in ovine Gram-negative sepsis

Ashenafi H Betrie, Shuai Ma, Connie PC Ow, Rachel M Peiris, Roger G Evans, Scott Ayton, Darius JR Lane, Adam Southon, Simon R Bailey, Rinaldo Bellomo, Clive N May, Yugeesh R Lankadeva

2023-09-01

Aim: Renal medullary hypoperfusion and hypoxia precede acute kidney injury (AKI) in ovine sepsis. Oxidative/nitrosative stress, in..

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Continuous bladder urinary oxygen tension as a new tool to monitor medullary oxygenation in the critically ill

RT Hu, YR Lankadeva, F Yanase, EA Osawa, RG Evans, R Bellomo

2022-12-01

Acute kidney injury (AKI) is common in the critically ill. Inadequate renal medullary tissue oxygenation has been linked to its pa..

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Role of perioperative hypotension in postoperative acute kidney injury: a narrative review

YR Lankadeva, CN May, R Bellomo, RG Evans

2022-06-01

Perioperative hypotension is common and associated with poor outcomes, including acute kidney injury (AKI). The mechanistic link b..

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Rapid and persistent decrease in brain tissue oxygenation in ovine gramnegative sepsis

N Okazaki, YR Lankadeva, RM Peiris, IE Birchall, CN May

2021-12-01

The changes in brain perfusion and oxygenation in critical illness, which are thought to contribute to brain dysfunction, are uncl..

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Therapeutic potential of megadose vitamin C to reverse organ dysfunction in sepsis and COVID-19

CN May, R Bellomo, YR Lankadeva

2021-10-01

Sepsis induced by bacteria or viruses can result in multiorgan dysfunction, which is a major cause of death in intensive care unit..

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Targeting oxidative stress in septic acute kidney injury: From theory to practice

CPC Ow, A Trask-Marino, AH Betrie, RG Evans, CN May, YR Lankadeva

2021-09-01

Sepsis is the leading cause of acute kidney injury (AKI) and leads to increased morbidity and mortality in intensive care units. C..

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Urinary and renal oxygenation during dexmedetomidine infusion in critically ill adults with mechanistic insights from an ovine model

MP Plummer, YR Lankadeva, ME Finnis, A Harrois, C Harding, RM Peiris, N Okazaki, CN May, RG Evans, CM Macisaac, D Barge, R Bellomo, AM Deane

2021-08-01

Purpose: Examine effects of dexmedetomidine on bladder urinary oxygen tension (PuO<inf>2</inf>) in critically ill patients and del..

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Renal functional reserve: from physiological phenomenon to clinical biomarker and beyond

Alemayehu H Jufar, Yugeesh R Lankadeva, Clive N May, Andrew D Cochrane, Rinaldo Bellomo, Roger G Evans

2020-12-01

Glomerular filtration rate (GFR) is acutely increased following a high-protein meal or systemic infusion of amino acids. The mecha..

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